Allelic Variation in the Vitamin D Receptor Gene Is Associated with Multiple Sclerosis in an Australian Population

نویسندگان

  • Lotti Tajouri
  • Micky Ovcaric
  • Rob Curtain
  • Rod Lea
  • Matthew Johnson
  • Peter Csurhes
  • Michael P. Pender
  • Lyn R. Griffiths
چکیده

Lotti Tajouri, Micky Ovcaric, Rob Curtain, Rod Lea, Matthew Johnson, Peter Csurhes, Michael P. Pender and Lyn R. Griffiths Genomics Research Centre, School of Health Science, Griffith University Gold Coast, Southport, Queensland, Australia 4215 2Neuroimmunology Research Centre, School of Medicine, University of Queensland; and Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Brisbane, Queensland, Australia 4029 3 Institute for Molecular Systematics, School of Biological Sciences, Victoria University, Wellington, New Zealand.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients

Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...

متن کامل

Effect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis

Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...

متن کامل

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population.

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, Taq I and Fok I) in an Australian MS case-control population. One hundred and f...

متن کامل

Investigation of genetic variation of IL-4 receptor rs1801275 in patients with multiple sclerosis in Isfahan

Aim and Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease that attacks myelinated axons in the central nervous system (CNS) resulting in destroying the myelin and the axon. According to high prevalence of disease in Iran, it needs to study different aspects of disease including factors influencing the pathogenesis and the other risk factors. Various type of genetic varia...

متن کامل

The role of polymorphism of TaqI in Vitamin D receptor gene and risk of ovarian cancer in women of North India

Background & objective: Ovarian cancer mortality is associated with lower regional sunlight exposure. Vitamin D and its metabolites are best known for their action in calcium and bone metabolism. However, epidemiological studies have suggested that an increased ovarian cancer risk is associated with decreased production of vitamin D. The vitamin D signaling pathway is involved in a wide variety...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005